Shien-Fong Lin
Job title Professor
Name Shien-Fong Lin
Office Tel No. 03-5712121ext54040
Research expertise Biomedical informatics
class CM A
Academic status Graduated
grade Fourth grade
Mentor 0
Year of Entrance 1974
Year of graduate 1978
Year Paper Title
2013 Zhang H, Joung B, Shinohara T, Mei X, Chen PS, Lin SF. Synergistic dual automaticity in sinoatrial node cell and tissue models. Circ J. 2010;74:2079-2088
2013 Shinohara T, Joung B, Kim D, Maruyama M, Luk HN, Chen PS, Lin SF. Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium. Heart Rhythm. 2010;7:110-116
2013 Shinohara T, Park HW, Han S, Shen MJ, Maruyama M, Kim D, Chen PS, Lin SF. Ca2+ clock malfunction in a canine model of pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2010;299:H1805-1811
2013 Maruyama M, Joung B, Tang L, Shinohara T, On YK, Han S, Choi EK, Kim DH, Shen MJ, Weiss JN, Lin SF, Chen PS. Diastolic intracellular calcium-membrane voltage coupling gain and postshock arrhythmias: Role of purkinje fibers and triggered activity. Circ Res. 2010;106:399-408
2013 Kim D, Shinohara T, Joung B, Maruyama M, Choi EK, On YK, Han S, Fishbein MC, Lin SF, Chen PS. Calcium dynamics and the mechanisms of atrioventricular junctional rhythm. J Am Coll Cardiol. 2010;56:805-812
2013 Joung B, Lin SF, Chen Z, Antoun PS, Maruyama M, Han S, Piccirillo G, Stucky M, Zipes DP, Chen PS, Das MK. Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation. Heart Rhythm. 2010;7:88-95
2013 Joung B, Shinohara T, Zhang H, Kim D, Choi EK, On YK, Piccirillo G, Chen PS, Lin SF. Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition. Am J Physiol Heart Circ Physiol. 2010;299:H634-642
2013 Efimov IR, Fedorov VV, Joung B, Lin SF. Mapping cardiac pacemaker circuits: Methodological puzzles of the sinoatrial node optical mapping. Circ Res. 2010;106:255-271
2013 Choi EK, Shen MJ, Han S, Kim D, Hwang S, Sayfo S, Piccirillo G, Frick K, Fishbein MC, Hwang C, Lin SF, Chen PS. Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs. Circulation. 2010;121:2615-2623
2013 Chen PS, Choi EK, Zhou S, Lin SF, Chen LS. Cardiac neural remodeling and its role in arrhythmogenesis. Heart Rhythm. 2010;7:1512-1513
2013 Chen PS, Joung B, Shinohara T, Das M, Chen Z, Lin SF. The initiation of the heart beat. Circ J. 2010;74:221-225
2013 Chen PS, Maruyama M, Lin SF. Arrhythmogenic foci and the mechanisms of atrial fibrillation. Circ Arrhythm Electrophysiol. 2010;3:7-9
2013 Han S, Koyayashi K, Joung B, Piccirillo G, Maruyama M, Vinters HV, March K, Lin S-F, Shen C, Fishbein MC, Chen P-S, Chen LS. Electroanatomical remodeling of the left stellate ganglion after myocardial infarction.  JACC (in press)
2013 Shinohara T, Park H-W, Joung B, Maruyama M, Chua S-K, Han S, Shen MJ, Chen P-S, Lin S-F. Selective sinoatrial node optical mapping and the mechanism of sinus rate acceleration.  Circ J (in press)
2013 Joung B, Hwang H-J, Pak H-N, Lee M-H, Shen C, Lin S-F, Chen P-S. Abnormal Response of Superior Sinoatrial Node to Sympathetic Stimulation is a Characteristic Finding in Patients with Atrial Fibrillation and Symptomatic Bradycardia. Circulation: Arrhythmia & Electrophysiology (in press)
2013 Shou W. Restrictive loss of Plakoglobin in cardiomyocytes leads to Arrhythmogenic Cardiomyopathy. Human Molecular Genetics (in press)
2013 Kawase A, Karagueuzian H. Spontaneous Atrial Fibrillation Initiated by Tyramine in Canine Atria with Increased Sympathetic Nerve Sprouting. JCE (in press)
2013 Shinohara T, Shen MJ, Han S, Maruyama M, Park H-W, Fishbein M, Shen C, Chen P-S, Lin S-F. Heart Failure Decreases Nerve Activity in the Right Atrial Ganglionated Plexus. JCE (in press)
2013 Wu TJ, Lin S-F, Hsieh YC, Lin TC, Lin J-C, Ting CT. Pre-treatment of BAPTA-AM Suppresses the Genesis of Repetitive Endocardial Focal Discharges and Pacing-Induced Ventricular Arrhythmia during Global Ischemia. JCE (in press)
2013 Maruyama M, Li B-Y, Chen H, Xu X, Song L-S, Zhu W, Yong W, Bu G-X, Lin SF, Fishbein MC, Lederer J, Schild JH, Field LJ, Rubart M, Chen P-S, Shou W. FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res (in press)
2013 Maruyama M, Lin SF, Chen PS. Alternans of diastolic intracellular calcium elevation as the mechanism of bidirectional ventricular tachycardia in a rabbit model of Andersen-Tawil syndrome. Heart Rhythm. 2010 (epub)
2013 Shen MJ, Shinohara T, Park H-W, Frick K, Ice DS, Choi E-K, Han S, Maruyama M, Sharma R, Shen C, Fishbein M, Chen LS, Lopshire JC, Zipes DP, Lin S-F, Chen P-S. Chronic low-level vagal nerve stimulation reduces stellate ganglion nerve activity and paroxysmal atrial tachyarrhythmias in ambulatory canines. Circulation 2011;123:2204-2212
2013 Chua S-K, Chang P-C, Maruyama M, Turker I, Shinohara T, Shen MJ, Chen Z, Changyu S, Rubart-von der Lohe M, Lopshire JC, Ogawa M, Weiss J, Lin S-F, Ai T, Chen P-S: Small Conductance Calcium Activated  Potassium Channel and Recurrent Ventricular Fibrillation in Failing Rabbit Ventricles.  Circ Res  2011;108:971-979
2013 Shen MJ, Choi EK, Tan AY, Han S, Shinohara T, Maruyama M, Chen LS, Shen C, Hwang C, Lin SF, Chen PS. Patterns of baseline autonomic nerve activity and the development of pacing-induced sustained atrial fibrillation. Heart Rhythm 2011;8:583-589
2013 Joung B, Park HW, Maruyama M, Tang L, Song J, Han S, Piccirillo G, Weiss JN, Lin SF, Chen PS. Intracellular calcium and the mechanism of anodal supernormal excitability in Langendorff perfused rabbit ventricles. Circ J. 2011;75:834-843
2013 Maruyama M, Lin SF, Xie Y, Chua SK, Joung B, Han S, Shinohara T, Shen MJ, Qu Z, Weiss JN, Chen PS. Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome. Circ Arrhythm Electrophysiol. 2011;4:103-111
2013 Joung B, Chen PS, Lin SF. The Role of the Calcium and the Voltage Clocks in Sinoatrial Node Dysfunction. Yonsei Med J. 2011 Mar;52(2):211-219
2013 Zhang H, Ueyama T, Wang J, Wu R-J, Lin S-F. Short-term memory and electrical restitution in the canine transmural ventricle. Physiol. Meas. 2011;32:207-222.

2013 Joung B, Zhang H, Shinohara T, Maruyama M, Han S, Kim D, Choi EK, On YK, Lin SF, Chen PS. Delayed afterdepolarization in intact canine sinoatrial node as a novel mechanism for atrial arrhythmia. J Cardiovasc Electrophysiol. 2011;22:448-454
2013 Lee YS, Maruyama M, Chang PC, Park HW, Rhee K-S, Hsieh Y-C, Hsueh C-H, Shen C, Lin S-F, Hwang HS, Knollmann BC, Chen P-S. Ryanodine Receptor Inhibition Potentiates the Activity of Na channel Blockers Against Spontaneous Calcium Elevations and Delayed Afterdepolarizations in Langendorff-Perfused Rabbit Ventricles. Heart Rhythm (accepted, 2/23/12
2013 Chen P-S, Ogawa M, Maruyama M, Chua S-K, Chang P-C, Rubart-von der Lohe M, Chen Z, Ai T, Lin S-F. Imaging arrhythmogenic calcium signaling in intact hearts. Pediatr Cardiol (Review)
2013 Park H-W, Shen MJ, Lin S-F, Fishbein MC, Chen LS, Chen P-S. Neural mechanisms of atrial fibrillation.  Current Opinion in Cardiology 20121:24-28

Year Paper Title
2013  Lin S-F, Rohde GK, Bray M, Aldroubi A. Wavelet denoising of epicardial fluorescence imaging.  Wavelet Applications in Signal and Imaging Processing IV, SPIE Symposium. 1998
2013 Pitruzzello AM, Woods MC, Wikswo JP, Jr., Lin S-F. Differences in cardiac activation times for endocardium and epicardium in response to external electric shock. Proceedings of the First Joint BMES/EMBS Conference 1999;6:55.
2013 Lin S-F, Han J, Qian YW, Province RR, Sung J. Virtual Electrodes in the termination of ventricular fibrillation in protective zones,. Proceedings of the First Joint BMES/EMBS Conference. 1999;5:55.
2013 Woods M, Pitruzzello A, Lin S-F, Wikswo JP, Jr. Effects of field stimulation on rabbit endocardium. 2nd Tennessee Conference on Biomedical Engineering. 1999: 63
2013 Serinagaoglu Y, Brooks DH, Wu TJ, Lin S-F. Bayesian multiresolution map estimation of edge or transition point location in noisy signals. International Conference on Acoustics, Speech and Signal Processing, IEEE, 2000
2013 Serinagaoglu Y, Brooks DH, Lin S-F, Macleod RS, Gaudette RJ. Bayesian Detection of Recovery Times in Optical Maps. 27th International Congress on Electrocardiology, 2000
2013 Rohde GK, Sidorov V, Aldroubi A, Dawant BM, Lin S-F. Correction of Motion Artifact in Cardiac Optical Mapping Using Image Registration Technique.  IEEE BMES/EMBS 2002
2013 Liu Y-B, Attin M, Chou C-C, Chen P-S, Lin S-F. Dynamic coupling between membrane potential and intracellular calcium in rabbit ventricles. BMES 2003
2013  Hernandez H, Hwang G-S, Lin S-F. Synchronization of ventricular fibrillation with electrical pacing guided by optical signals: Comparison of pacing locations.  SPIE Biomedical Optics 2006, Proc of SPIE Vol. 6078, 607820-1-6
2013  Tang L, Hwang G-S, Yang L, Lin S-F. Method of post-shock synchronized pacing in the excitable gap.  2006 IEEE International Conference of the Engineering in Medicine & Biological Society
2013  Song J, Ogawa M, Tan AY, Chen P-S, Lin S-F. Heart rate variability and autonomic nerve activities in ambulatory dogs. 2006 IEEE International Conference of the Engineering in Medicine & Biological Society
2013  Tang L, Cha Y-M, Li H, Chen P-S, Lin S-F. Fiber-optic immuno-biosensor for rapid and accurate detection of nerve growth factor in human blood. EMBC 2006
2013  Ho A, Tang L, Chiang F-P, Lin S-F. Comparison of Epicardial Deformation in Passive and Active Isolated Rabbit Hearts. SPIE Biomedical Optics 2007, Proc of SPIE Vol. 6424
2013  Lin S-F, Dubljevic S. Pacing real-time spatiotemporal control of cardiac alternans. IEEE Control Systems Society Conference, New York, NY 2007;600-606 (Winner of the O. Hugo Schuck Award)
2013  A. Shayan-Arani, Y. Zhu, Y.N. Cheng, C.K. Cheng, S.F. Lin, and P.S. Chen, "Exploring Cardioneural Signal from Noninvasive ECG Measurement," IEEE Symp. on Bioinformatics & Bioengineering 2007, pp1134-1138.
2013  Musunuri S, Tang L, Joung B, Berbari EJ, Lin S-F. Ventricular defibrillation combining DC electrical field and electrical pacing: an optical mapping study. Proc. SPIE 7182, 718214 (2009)
2013  Joung B, Tang L, Song J, Han S, Maruyama M, Piccirillo G, Shien-Fong Lin S-F, Chen P-S. Sodium-Calcium Exchanger Current Activation and Responses to Premature Stimulation in Langendorff-Perfused Rabbit Ventricles. 2nd Asia-Pacific Heart Rhythm Society Scientific Session 2009. (Best Paper Award) 
2013  Lin S-F, Shinohara T, Joung B, Chen P-S. Selective sinoatrial node optical mapping to investigate the mechanism of sinus rate acceleration. SPIE Photonics West: Biomedical Optics. 2011 Proc. SPIE 7883, 78832Z
Organization Title Job Title Duration
Indiana University School of Medicine Indianapolis, IN Professor of Medicine 2007.08 ~ 2013.08
Xi’an Jiaotong Univeristy, Shanxi, China Visiting Professor 2007.08 ~ 2010.08
David Geffen School of Medicine at UCLA Los Angeles, CA Associate Professor in Residence 2002.08 ~ 2007.08
Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA Research Scientist III 2001.08 ~ 2013.08
Department of Physics and Astronomy Vanderbilt University, Nashville, TN Research Associate and Research Assistant Professor 1992.08 ~ 2001.08
Department of Physiology Northwestern University Medical School, Chicago, IL Postdoctoral Fellow 1992.08 ~ 1992.08
Chicago Institute of NeuroSurgery and NeuroResearch Columbus Hospital, Chicago, Illinois Research Engineer 1988.08 ~ 1991.08